山奈酚 cas：520-尊龙凯时旗舰厅

中文别名：

山柰酚;山奈酚;3,4';5,7-四羟基黄酮;莰菲醇;百蕊草素ⅲ;山柰酚-3;山柰黄酮醇

英文名称:

kaempferol

英文别名：

3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;5,7,4’-trihydroxyflavonol;campherol;indigoyellow;kaempherol

沸点：

熔点：

277 °c

闪点：

密度：

1.6880

敏感性：

折光率：

溶解性：

外观：

产品介绍：

产品应用：

一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-h-ras-转化的 nih 3t3细胞变形后的恢复。能显著诱导核dna退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶i催化的dna再连接。

生化机理：

description： ic50 value: kaempferol inhibits proliferation of ovarian cancer cells at 40μm or higher concentrations[2]. kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one) is a relatively common nontoxic, natural dietary compound which has been reported to reduce the risk of ovarian cancer[1]. in vitro: kaempferol was found to inhibit estrogen receptor alpha expression in breast cancer cells and to induce apoptosis in glioblastoma cells and lung cancer cells by activation of mek-mapk. studies have shown that kaempferol also has anti-inflammatory effects via inhibition of interleukin-4 and cyclo-oxygenase 2 expression by suppressing src kinase and downregulating the nfκb pathway. kaempferol is also effective in inhibiting angiogenesis and inducing apoptosis in ovarian cancer cells [1]. kaempferol has a distinct epigenetic activity by inhibition of histone deacetylases (hdacs). in silico docking analysis revealed that it fits into the binding pocket of hdac2, 4, 7 or 8 and thereby binds to the zinc ion of the catalytic center. further in vitro profiling of all conserved human hdacs of class i, ii and iv showed that kaempferol inhibited all tested hdacs [4]. in vivo: male balb/c mice with ali, induced by intranasal instillation of lps, were treated or not with kae (100 mg/kg, intragastrically) 1h prior to lps exposure. kae treatment attenuated pulmonary edema of mice with ali after lps challenge, as it markedly decreased the lung w/d ratio of lung samples, protein concentration and the amounts of inflammatory cells in balf[3]. clinical trial:n/a

un码：

hazardclass：

36/37/38

危害：

xi

安全：

26-36

个人防护设备：

eyeshields,faceshields,gloves,type p2 (en 143) respirator cartridges

是否危化品：

储存条件：

store in a cool, dry area. 室温密封保存